Abstract
The management of canine atopic dermatitis, an allergic skin disorder, is challenging. To investigate the effect of phototherapy using a 308-nm excimer light as a topical treatment for canine atopic dermatitis, 10 dogs with canine atopic dermatitis and 10 with non-allergic skin were enrolled in this study. Phototherapy was applied every 7 days for a total of 2 months. The skin microbiome, skin barrier function, and clinical outcomes were evaluated after phototherapy. Phototherapy significantly changed the composition of the skin microbiome of dogs with atopic dermatitis and significantly increased the relative abundance of the phyla Actinobacteria and Cyanobacteria. It significantly alleviated the clinical signs of canine atopic dermatitis without serious adverse effects. Transepidermal water loss, as a measure of skin barrier function, significantly decreased after phototherapy. In addition, phototherapy increased microbial diversity and decreased the relative abundance of Staphylococcus pseudintermedius associated with the severity of canine atopic dermatitis. These results suggest that the excimer light therapy is a suitable and safe therapeutic option for canine atopic dermatitis, which is also a spontaneous animal model of atopic dermatitis.
Highlights
Canine atopic dermatitis is a chronic allergic dermatitis that affects approximately 10–15% of dogs [1, 2]
Six dogs were treated with excimer light monotherapy, three with excimer light therapy combined with oclacitinib, one with excimer light therapy combined with lokivetmab, with none of the dogs being treated with cyclosporine or systemic glucocorticoid
We examined the effect of topical 308nm excimer light therapy for Canine atopic dermatitis (cAD) on the skin microbiome, skin barrier function, and clinical outcomes
Summary
Canine atopic dermatitis (cAD) is a chronic allergic dermatitis that affects approximately 10–15% of dogs [1, 2]. Lokivetmab (an injectable anti-canine interleukin-31 [IL-31] monoclonal antibody) has been used as a new treatment option for atopic dermatitis (AD) [1]. Excimer light, which is a narrow-band UVB light at a 308-nm wavelength, acts topically. It can be Phototherapy for Canine Atopic Dermatitis safely applied as it has few known side effects, and its effectiveness has been proven for many human skin diseases such as plaque psoriasis and vitiligo [4,5,6]. Excimer light treatment was used effectively in human AD patients [4, 7]
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