Efficacy of Phloroglucinol vs Drotaverine Hydrochloride in Shortening in Primigravidae at Term the Active Phase of the First Stage of Labor

Abstract

Primigravida women are those who conceive for the first time and are at high risk group for complications during childbirth Objective: To compare the effectiveness of phloroglucinol i/v and drotaverine hydrochloride by measurement of the 1st stage of labor in primigravidae. Methods: This randomized controlled trial was held in the Obstetrics and Gynecology Department of Allama Iqbal Memorial Teaching Hospital Sialkot and The Indus hospital QF-NST Campus Lahore for six-months duration from July to December 2021. Several factors were used to determine the inclusion of primigravida females, including age range of 20- 35 years, 38-42 weeks of gestational age at LMP with single pregnancy, Uterine contractions up to 3 cm if they occur at 3-4, 10 minutes before both drugs are given, ROM, no signs of fetal and maternal distress, patient in the first stage of labour. All of the cases were divided into two groups: A and B. Group 'A' received phloroglucinol 40mg (4ml) i/v at 4 cm dilation, and the dosage was repetitive at 8 cm dilation. At 4cm dilation, Group 'B' received drotaverine 40mg i/v. The essential signs including uterine contractions and fetal heart rate were monitored every half an hour. Results: 80 patients were included, with 56.3% of cases in Group-A group B has 43.7% cases being between the ages of 20-35 years. There was a significant improvement in the first stage of active labour ’mean duration in Groups A and B is 160.21±4.29 minutes and 203.77±8.21 minutes, respectively. Conclusion: The mean active length of the 1st stage of labour in the group of phloroglucinol was substantially shorter than in the drotaverine group