Efficacy of penehyelidine hydrochloride for prevention of postoperative pulmonary complications in patients undergoing off-pump coronary artery bypass grafting

Abstract

Objective To evaluate the efficacy of penehyelidine hydrochloride for prevention of postoperative pulmonary complications (PPCs) in patients undergoing off-pump coronary artery bypass grafting (OPCABG).Methods One hundred and forty ASAⅡ or Ⅲ patients of both sexes,aged 35-80 yr,weighing 55-80 kg,undergoing OPCABG,were randomly divided into 2 groups (n =70 each):control group (group C) and penehyelidine hydrochloride group (group P).Anesthesia was induced with iv injection of midazolam,etomidate,sufentanil and rocuronium.The patients were mechanically ventilated after tracheal intubation.PET CO2 was maintained at 35-40 mm Hg.Penehyelidine hydrochloride 20μg/kg (5 ml) was injected intravenously and slowly immediately after tracheal intubation in group P.While the equal volume of normal saline was administered instead in group C.Anesthesia was maintained with iv infusion of propofol,intermittent iv boluses of sufentanil and pipecuronium,and inhalation of sevoflurane.BIS value was maintained at 40-50.The occurrence of PPCs was recorded within 72 h after operation.Results The incidences of PPCs were 33％ and 16％ in groups P and C,respectively.The incidence of PPCs was significantly lower in group P than in group C (P ＜ 0.05).Conclusion Intravenous injection of penehyelidine hydrochloride 20μg/kg before operation can prevent the occurrence of PPCs in patients undergoing OPCABG. Key words: Cholinergic antagonists; Coronary artery bypass, off-pump; Postoperative complications