Efficacy of oxycodone in preventing catheter-related bladder discomfort during recovery from anesthesia in patients undergoing general anesthesia

Abstract

Objective To evaluate the efficacy of oxycodone in preventing catheter-related bladder discomfort (CRBD) during recovery from anesthesia in the patients undergoing general anesthesia. Methods A total of 155 male patients, aged 18–60 yr, weighing 46–75 kg, of American Society of Anesthesiologists physical status Ⅰor Ⅱ, scheduled for elective spinal surgery performed under general anesthesia, were randomly divided into 3 groups: control group (group C, n=52), oxycodone group (group O, n=51), and sufentanil group (group S, n=52). After induction of anesthesia, the patients were tracheally intubated and mechanically ventilated.At 15 min before the end of surgery, oxycodone 0.07 mg/kg was injected intravenously in group O, sufentanil 0.10 μg/kg was injected intravenously in group S, and the equal volume of normal saline was given in group C. The emergence time and extubation time were recorded.Riker sedation-agitation scale (SAS) score was recorded at 5, 15 and 30 min, and 1, 2 and 4 h after extubation (T1-6). The occurrence and severity of CRBD within 4 h after surgery, and occurrence of nausea and vomiting and respiratory depression were observed and recorded. Results Compared with group C, the SAS score at T1-4 and incidence and severity of CRBD were significantly decreased, and the emergence time and extubation time were prolonged in group S, and the SAS score at T1-6 and incidence and severity of CRBD were significantly decreased (P 0.05). Compared with the group S, the SAS score at T1-4 was significantly increased, the SAS score at T5-6 and incidence and severity of CRBD were decreased, and the emergence time and extubation time were shortened in group O (P 0.05). Conclusion Oxycodone 0.07 mg/kg injected intravenously at 15 min before the end of surgery can prevent the occurrence of CRBD during recovery from anesthesia in the patients undergoing general anesthesia. Key words: Oxycodone; Anesthesia recovery period; Urinary catheterization