Efficacy of oxycodone combined with butorphanol in intravenous patient-controlled analgesia after thoracoscopic surgery

Abstract

Objective To evaluate the safety and efficacy of PCIA in the postoperative analgesic with oxycodone combined with butorphanol after thoracic surgery. Methods Patients received pulmonary obectomy under thoracoscope were divided into butorphanol group (164 cases) and combined group (194 cases) according to the kind of PCIA. Patients received postoperative analgesia with butorphanol only in the butorphanol group, while butorphanol and oxycodone in the combined group. VAS, times of press, total volume,Ramsay score and adverse reactions were recorded at each time points and time intervals after operation. Results VAS at rest was significantly lower at 6 and 24 h after the operation in the combined group than that in the butorphanol group (P<0.05). VAS during movement was lower at 24 h after the operation in the combined group (P<0.05). The times of press were lower during 6-8 h and 24-26 h after the operation in the combined group than those in the butorphanol group (P<0.05). The percentage of Ramsay score 3 was lower in combined group (P<0.05). Conclusion The efficacy of oxycodone combined with butorphanol is superior to butorphanol only in the intravenous patient-controlled analgesic after thoracic operation, with fewer adverse effects. Key words: Oxycodone; Butorphanol; Thoracic procedures; Pain, post-operative; Analgesia, patient-controlled