Abstract
Objective The purpose of this study was to evaluate the wound healing efficacy of oxidized regenerated cellulose (ORC)/collagen dressing and ORC/collagen/silver-ORC dressings compared to standard of care or control in treatment of chronic skin wounds such as diabetic foot ulcers (DFUs), venous leg ulcers (VLUs), and pressure injuries sore ulcers (PISUs). Methods An electronic search was carried out in four popular databases PubMed, Scopus, Embase, and CENTRAL to identify thirteen included studies, comparing the clinical efficacy of ORC/collagen dressings when compared to control in management of chronic skin wounds, especially DFUs, VLUs, and PISUs, and skin graft donor site wounds. Results Consolidated data from thirteen comparative clinical studies undertaken for management of DFUs, VLUs, and PISUs showed favorable outcomes towards use of ORC/collagen compared to other traditional and hydrocolloid foam dressings in terms of wound healing rate (P=0.02) and percentage wound relative reduction (P=0.003). The time taken to achieve complete wound healing in the included studies did not show any statistical significant difference (P=0.24). There was no significant difference in adverse events between ORC/collagen-treated group and comparative group (P=0.19). Conclusion ORC/collagen wound dressings are beneficial in terms of improved wound healing rate and percentage wound relative reduction compared to already existing traditional standard of care with non-MMP, inhibiting biomaterials such as moistened gauze, autologous growth factors, hydrocolloid foam dressings, or ovine extracellular matrix.
Highlights
Wound is defined as a disruption in cutaneous structure and function, potentially involving underlying soft tissue [1]
What is the wound healing efficacy of oxidized regenerated cellulose (ORC)/collagen dressing and ORC/collagen/silver-ORC dressings compared to standard of care or control in the treatment of chronic skin wounds? Patient or population (P): participants with chronic skin wounds (DFUs, venous leg ulcers (VLUs), PIs, etc.); intervention (I): wound dressing with ORC/collagen or ORC/collagen/silver-ORC dressings; comparison (C): standard of wound care or control; outcome (O): wound healing rate, wound reduction, time taken for complete healing, adverse events, etc
Search Results. is systematic review assessed the data from 13 included studies [13, 15, 20,21,22,23,24,25,26,27,28,29,30] comparing the clinical efficacy of ORC/collagen dressings when compared to control in the management of chronic skin wounds, especially diabetic foot ulcers (DFUs), VLUs, and PIs. e electronic search was carried out in all 4 databases and the manual search retrieved 699 articles, where the total studies identified were 545 after removal of duplicates
Summary
Wound is defined as a disruption in cutaneous structure and function, potentially involving underlying soft tissue [1]. Various factors that can result in impaired wound healing include aging, malnutrition, diabetes, vascular disease, and immunosuppression [2]. Prolongation of the inflammatory phase is the most common cause, usually due to wound infection or chronic irritation. Other possible mechanisms are tissue and wound hypoxia or failed epithelialization [3]. Surgeons sometimes reexcise the tissue and convert the chronic wound back into an acute one for faster healing and tissue regeneration [4]. E ultimate requirement for complete wound healing involves proper nursing of wound by application of wound dressings or wound care products [5]. Surgeons sometimes reexcise the tissue and convert the chronic wound back into an acute one for faster healing and tissue regeneration [4]. e ultimate requirement for complete wound healing involves proper nursing of wound by application of wound dressings or wound care products [5]. e wound dressings used in management of chronic wounds needs to be cost-effective and clinically efficient, high patient acceptance, and most importantly improved patient’s quality of life [6]
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