Abstract
Background: Intrathecal neostigmine and magnesium sulfate (MgSO4) produce substantial antinociception, potentiate analgesia of bupivacaine without neurotoxicity. The aim of the study was to investigate the effect of neostigmineAims: and MgSO4 on characteristics of spinal anesthesia (SA), hemodynamic stability and postoperative analgesia when added to 0.5% hyperbaric bupivacaine for SA. In this prospective, randomized, single-blindSubjects and Methods: study 90 American Society of Anesthesiologist status I and II adult males and females posted for major lower abdominal surgery were assigned to one of the three groups (n = 25). Group N received Neostigmine 50
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