Efficacy of Nefopam in multimodal analgesia in dogs

Abstract

Pain that occurs in a surgical patient in the area of surgical intervention is called surgical pain. Postoperative analgesia is one of the most important components in the system of general intensive care, which creates comfortable living conditions for the surgical patient. In veterinary practice, the central non-opioid analgesic Nefopam has become available, which has a structural affinity for diphenhydramine (Diphenhydramine) and orphenadrine and has both spinal and supraspinal mechanisms of action. The aim of the study is to evaluate the efficacy and safety of Nefopam as part of multimodal analgesia in the postoperative period in dogs. For the study were selected 20 dogs aged 1 to 10 years who underwent radical surgery requiring multicomponent anesthesia. The animals were divided into 2 groups of 10 dogs each. Surgical interventions were performed under conditions of general combined anesthesia according to standard protocols of the clinic using neuroleptics, anesthetics, non-narcotic painkillers. In the postoperative period, a non-opioid centrally acting analgesic, Nefopam, was introduced into the scheme of multimodal analgesia in the animals of the experimental group, and Analgin was administered to the dogs of the control group. The level of pain of the visual analog scale for assessing pain according to VAS. To assess the health status of experimental animals before surgery and on the 3rd and 7th days after it, blood was taken for biochemical and clinical studies. The use of Nefopam in the complex of multimodal analgesia used in the clinic is therapeutically justified and effective. It is this kind of analgesia that makes it possible to fully and safely anesthetize patients after extensive and traumatic operations with minimal consumption of non-opioid and opioid analgesics.