Efficacy of nalbuphine combined with propofol for painless hysteroscopy in patients with functional uterine bleeding

Abstract

Objective To observe the efficacy of nalbuphine combined with propofol for painless hysteroscopy in patients with functional uterine bleeding. Methods One hundred and twenty outpatients with functional uterine bleeding, aged 28-45 years old, underwent painless hysteroscopy from July to December 2017 in Tianjin Beichen Women and Children Health and Family Planning Center, ASAⅠor Ⅱ, were divided into propofol group and combined drug group with double-blind method randomly, sixty cases in each group. Only propofol was used in propofol group, and nalbuphine combined with propofol was used in combined drug group. Painless hysteroscopy was performed after the eyelash reflex disappeared and no call-response. The changes of MAP, HR and SpO2 were observed at the time of entering the operation room, eyelash reflex disappearance, cervical dilatation and consciousness recovery. Postoperative consciousness recovery time, intraoperative propofol dosage and VAS were recorded. Results Compared with the time of entering the operation room, the hemodynamic parameters decreased at the time of eyelash reflex disappearance, cervical dilatation and consciousness recovery in the two groups (P<0.05). The hemodynamic parameters decreased more obviously in propofol group as compared with combined drug group (P<0.05). The total dose of propofol and VAS were higher in propofol group than those in combined drug group (163±12 vs. 128±11, 2.1±0.8 vs. 0.8±0.1, P<0.05). Conclusion The analgesic effect of nalbuphine combined with propofol for painless hysteroscopy in patients with functional uterine bleeding is significant, with stable hemodynamics and fewer adverse reactions as compared with only propofol. Key words: Nalbuphine; Propofol; Hysteroscopy; Uterine hemorrhage