Abstract

Objective: The aim of this study was to compare the efficacy of MTAD (a mixture of a tetracycline isomer, an acid, and a detergent), Er:YAG laser, 17% EDTA, and 5.25% NaOCl in removing the smear layer from the surface of instrumented root canals. 
 Materials and Methods: Various organic acids, instruments and lasers have been used to remove the smear layer from the surface of instrumented root canals. Twenty-eight extracted maxillary and mandibular incisors were prepared with rotary files. The teeth were randomly allocated to four treatment groups for final irrigation as follows: (1) 17% EDTA (followed by NaOCl), (2) 5.25% NaOCl, (3) Er:YAG laser, and (4) MTAD. All teeth were processed for scanning electron microscopy (SEM) and the removal of the smear layer was examined in the apical, middle and coronal thirds. 
 Results: At coronal location, NaOCl(2.2±0.4) group had significantly higher scores than MTAD(0.0±0.0), EDTA(0.6±0.4) and Er:YAG laser(0.6±0.4) groups (p

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