Abstract
Objective: This study aimed at comparing the antiplaque, anticalculus, and antigingivitis potentials of a mouth rinse containing essential oil, alcohol,zinc, and fluoride with a mouth rinse containing cetylpyridinium chloride (CPC) 0.1% over 1-, 2-, and 3-month periods.Methods: This study was a double-blind, parallel randomized clinical trial with a 3-day run-in phase. Respondents were asked to gargle twice dailywith 15 ml of mouth rinse for 30 seconds after brushing teeth. Respondents were 80 females with a mean age of 21 years, and a single dental examinerwas employed throughout the study to decrease the variance. Prophylaxis was performed for all respondents before the intervention. Three mouthrinses were tested: Group 1 with the mouth rinse containing CPC 0.1%, Group 2 as the negative control, and Group 3 as the positive control with amouth rinse containing alcohol. Evaluations were conducted by plaque index, gingival index, calculus index, and CariScreen examinations.Results: The clinical trial showed that the mouth rinse with alcohol and the mouth rinse containing CPC 0.1% were effective in inhibiting bacterialbuildup (antiplaque) and have anticalculus properties, but with no statistically significant antigingivitis effect.Conclusion: It was found that the mouth rinse containing alcohol has similar effectiveness with CPC 0.1% mouth rinse, but side effects, such as aburning sensation, were reported in the alcohol-containing mouth rinse.
Highlights
Oral biofilms relate to the development and severity of gingivitis and periodontitis
cetylpyridinium chloride (CPC)-containing mouth rinses are indicated for regular daily use and are aimed at preventing and controlling biofilms and gingivitis [3]
CPC may decrease gingival inflammation provided by this agent when used in combination with either supervised or unsupervised oral hygiene [6]
Summary
Oral biofilms relate to the development and severity of gingivitis and periodontitis. Controlling for oral biofilm plays a key role in the prevention, treatment, and decrease of the recurrence of periodontal diseases [1]. This relationship has long been recognized, adequate self-performed biofilm control, such as brushing and rinsing with oral health products, still remains an area with the opportunity for improvement. There are several over-the-counter products to control plaque buildup, such as mouth rinses containing cetylpyridinium chloride (CPC), and there are various concentrations of CPC in mouth rinses. CPC-containing mouth rinses are indicated for regular daily use and are aimed at preventing and controlling biofilms and gingivitis [3]. An additional study about CPC-containing mouth rinses supported the benefit of CPC in decreasing plaque accumulation. A group of Indonesians was selected to be the study population to test this new formula, because the literature has shown higher prevalence and severity of gingivitis in developing countries than in populations in developed countries
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