Efficacy of misoprostol in reducing the time and easiness the insertion of Levonorgestrel-releasing intrauterine device; Randomized controlled trial

Abstract

Background: intrauterine devices (IUDs) have gained significant popularity as a prevalent form of reversible contraception. Levonorgestrel-releasing intrauterine devices (LNG-IUDs) have been found to be safe and cost-effective over an extended period. Furthermore, their efficacy is comparable to that of tubal sterilization. Aim: The aim of our study to reveled the effect of vaginal misoprostol on timing and the easiness of insertion of (LNG-IUDs) in previous cesarean sections women. Materials and method: One-hundred and eighty patients with a previous cesarean section attending for Mirena LNG-IUD insertion. This Randomized controlled trial set in Outpatient clinic in Department of Obstetrics and Gynecology, Faculty of Medicine, Helwan University Hospital at BADR city from March 2021 to March 2022. The current research assessed the effectiveness of 400mcg vaginal misoprostol 6 hours before LNG-IUD insertion in women who had only had a cesarean section before. Results: one hundred- eighty patients included in our Randomized control trial. Our results; There was statistically insignificant terms of anticipated pain, Pain after 20 min and satisfaction p-value>0.05.While, we found a statistically significant difference in Ease of insertion, Pain at insertion and Insertion time <0.001. Moreover, there was no statistically significant nausea, vomiting, shivering, fever, and need additional analgesia p-value>0.05. Conclusion: misoprostol is safe and effective in insertion the LNG-IUD because of the significant result in reduction of pain, timing and easiness of insertion.