Efficacy of microneedling with injectable platelet-rich fibrin (i-PRF) for facial skin rejuvenation

Abstract

Objective: Autologous blood concentrates have been used in the field of aesthetics for more than two decades. Injectable platelet-rich fibrin (i-PRF) remains more advantageous than other concentrates because it can both initiate fibrin clotting and preserve the secretion of growth factors to promote tissue repair. This study was performed to assess the effectiveness of microneedling therapy with i-PRF for facial skin revitalization using validated patient-reported outcome measures. Methods: Twelve patients with facial wrinkles were enrolled in the study. Their ages ranged from 26 to 71 years. Three i-PRF therapy sessions were offered at 4-week intervals. The patients’ photographs were taken at all sessions without exception and throughout the treatment course. The results were clinically evaluated after the final stage of therapy. All 12 patients’ data were statistically analyzed. Results: Three i-PRF sessions resulted in moderate improvement in the patients’ skin texture, color, and elasticity as well as filling of soft wrinkles. Statistically significant improvement was found in both skin elasticity (P = 0.02) and filling of soft wrinkles (P = 0.001). No complications occurred in any of the three treatment sessions, and the treatments were well tolerated by all patients. Conclusions: The literature indicates that i-PRF has been a favorable substitute for platelet-rich plasma in all settings in which it has been used. Nevertheless, further trials involving large numbers of patients are required to verify the promising results of i-PRF in the field of dermatology.