Abstract
Melissa officinalis is a plenteous source of antioxidant flavonols and flavonoids that contain health-promoting and antidiabetic properties, so this study was undertaken to provide the first assessment of the antidiabetic properties of hydroalcoholic extract of M.officinalis in type 2 diabetic patients. We did a randomized, placebo-controlled trial which included 62 patients, receiving either M.officinalis capsules (700mg/d; n=31) or the placebo (n=31) twice daily for 12weeks. There were significant differences in serum FBS (P=0.007), HbA1c (P=0.002), β-cell activity (P=0.05), TG (P=0.04), HDL-c (P=0.05), hs-CRP (P=0.001), and systolic blood pressure (P=0.04) between the two groups at the end of the study; but total cholesterol, LDL-c, insulin, and HOMA-IR showed no significant changes between the groups. In M.officinalis group, there was a significant change in HDL-c (P=0.009) and QUICKI (P=0.005) compared with baseline values. No adverse effects were observed. It seems that M.officinalis is safe and effective in improvement of lipid profile, glycemic control, and reduction of inflammation.
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