Efficacy of locally produced Latanoprost in the control of intraocular pressure in patients with primary open-angle glaucoma.

Abstract

To determine the efficacy of locally produced Latanoprost in reducing the intraocular pressure (IOP) in patients with Primary open-angle glaucoma (POAG). Open-label, non-comparative, observational case study with non-probability purposive sampling. A total of 48 patients (94 eyes) of either gender were recruited from glaucoma clinic with the diagnosis of POAG, having IOP of more than 21mmHg. Patients were commenced on locally produced Latanoprost (Vislat 0.005%). IOP was subsequently measured at 4weeks and 12weeks, respectively. The primary end point was reduction in IOP at 12weeks after the initiation of treatment. A total of 48 patients (94 eyes) were recruited from glaucoma clinic. The average IOP of our patients at baseline was 28.6±8.1mmHg, decreasing to 21.3±10.6mmHg at 4weeks, indicating a drop of 19.1% (P<0.001). IOP further decreased to 20.3±8.7mmHg after 3months of treatment indicating a decrease of 23.3% (P<0.001). A decrease in IOP occurred in 51 eyes (71.8%) at 4weeks after treatment, improving to 54 eyes (76%) at 3-month follow-up. Twenty eyes (28.1%) did not show any change in IOP at 4weeks. However, after 3-month follow-up only 17 eyes (23.9%) did not reveal any change in IOP. Our results showed a decrease in IOP of 19.1% after 4weeks, increasing to 23.3% at 12weeks in cohort of 37 patients (72 eyes) treated with locally produced Latanoprost (Vislat 0.005%).