Efficacy of Lipo PGE1 on severe chronic pulmonary heart disease patients combined with pulmonary hypertension

Abstract

Objective To evaluate the effects of Lipo PGE1 on severe chronic pulmonary heart disease patients combined with pulmonary hypertension.Methods Sixty-eight cases of severe chronic pulmonary heart disease combined with pulmonary hypertension were randomly divided into treatment group (34 cases) and control group(34 cases).Both groups received the conventional antibiotics,oxygen therapy and other treatments,and 10 μg Lipo PGE1 were added to the treatment group every day.Serum CNP,ADM levels and pulmonary artery pressure,arterial oxygen tension (PaO2),partial pressure of arterial blood sputum dioxide (PaCO2) were measured before and after the treatment.Results After treatment,blood CNP,ADM levels and pulmonary artery pressure,PaCO2 was significantly lower than those before treatment,PaO2 was significantly higher than that before treatment.There were significant difference between the treatment group and the control group (P ＜ 0.05).Conclusions Lipo PGE1 can significantly reduce the serum CNP,ADM levels and pulmonary artery pressure of patients of chronic pulmonary heart disease combined with pulmonary hypertension,and improve the cardiac function,pulmonary hypertension and arterial blood gas. Key words: Lipo PGE1; C-type natriuretic peptide; Adrenomedullin; Pulmonary hypertension; Arterial blood gas