Efficacy of linezolid in treatment of ventilator-associated pneumonia induced by MRSA

Abstract

Objective To compare the efficacy and safety of linezolid and vancomycin in the treatment of methicillin-resistant Staphylococcus aureus (MRSA) induced ventilator-associated pneumonia in intensive care unit.Methods In randomized controlled trials,62 patients with MRSA-induced ventilator-associated pneumonia in intensive care unit were randomly divided into two groups.Linezolid group (n =28) were administered with linezolid 600 mg every 12 hours for 14 days,ivgtt.Vancomycin group (n =34) were given vancomycin 1 000 mg every 12 hours for 14 days,ivgtt.Adverse events and the efficacy of two groups were investigated.Results The effective rates in linezolid group and vancomycin group were 78.57％ and 52.94％ (P ＜0.05).The adverse reaction rates in linezolid group and vancomycin group were 10.71％ and 14.71％.Conclusions Linezolid has positive effect in the treatment of MRSA induced ventilator-associated pneumonia. Key words: Linezolid; Methicillin-resistant Staphylococcus aureus; Ventilator-associated pneumonia