Abstract

Objective To compare the efficacy and safety of linezolid and vancomycin in the treatment of methicillin-resistant Staphylococcus aureus (MRSA) induced ventilator-associated pneumonia in intensive care unit.Methods In randomized controlled trials,62 patients with MRSA-induced ventilator-associated pneumonia in intensive care unit were randomly divided into two groups.Linezolid group (n =28) were administered with linezolid 600 mg every 12 hours for 14 days,ivgtt.Vancomycin group (n =34) were given vancomycin 1 000 mg every 12 hours for 14 days,ivgtt.Adverse events and the efficacy of two groups were investigated.Results The effective rates in linezolid group and vancomycin group were 78.57% and 52.94% (P <0.05).The adverse reaction rates in linezolid group and vancomycin group were 10.71% and 14.71%.Conclusions Linezolid has positive effect in the treatment of MRSA induced ventilator-associated pneumonia. Key words: Linezolid; Methicillin-resistant Staphylococcus aureus; Ventilator-associated pneumonia

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