Abstract
BackgroundThis study aims to evaluate the efficacy of limb salvage with primary tumor resection on patients with solitary bone metastasis.MethodsA retrospective treatment outcome review was performed on 20 patients with solitary bone metastasis as the primary clinical symptom who were admitted to the hospital between 2006 and 2010. With primary tumor resection, 18/20 patients received limb salvage surgery simultaneously. Pain scoring was assessed using the 0 to 10 numerical rating scale. The quality of life scoring was performed before and 3 months after surgery using the SF-30 scoring system. In addition, limb function was assessed 3 months after the operation using the Scoring System of American Musculoskeletal Tumor Society system (MSTS).ResultsThe pain symptom was significantly ameliorated after the operation (t = 26.653, P < 0.001), and the quality of life dramatically improved (t = −20.581, P < 0.001). The postoperative MSTS scores ranged from 18 to 27. The average score was 23.10 ± 2.36. The Kaplan-Meier analysis showed that no significant differences (χ2 = 1.589, P = 0.207) were observed in the tumor-free survival time between the wide and marginal resections.ConclusionsThe application of the wide or marginal excision for the primary lesion and bony metastasis focus, based on the principles of primary bone tumors, can significantly relieve the pain and improve the quality of life and limb function of patients whose solitary bone metastasis was manifested as the first sign.Electronic supplementary materialThe online version of this article (doi:10.1186/s12957-016-0786-8) contains supplementary material, which is available to authorized users.
Highlights
This study aims to evaluate the efficacy of limb salvage with primary tumor resection on patients with solitary bone metastasis
The application of the wide or marginal excision for the primary lesion and bony metastasis focus, based on the principles of primary bone tumors, can significantly relieve the pain and improve the quality of life and limb function of patients whose solitary bone metastasis was manifested as the first sign
Bone metastases often occur in some cancers, including breast cancer, prostate cancer, kidney cancer, thyroid cancer, and lung cancer, of which breast cancer and prostate cancer take the lead [1]
Summary
This study aims to evaluate the efficacy of limb salvage with primary tumor resection on patients with solitary bone metastasis. The bone is one of the most likely metastatic sites just following the lung and the liver. Bone metastases often occur in some cancers, including breast cancer, prostate cancer, kidney cancer, thyroid cancer, and lung cancer, of which breast cancer and prostate cancer take the lead [1]. Seventy percent of bone metastases occur in the axial skeleton, while 10 %. Limb bone metastases occur in the proximal long bones, such as the proximal humerus and the proximal femur [2]. Patients with bone metastases often experience severe complications, including pain, limited mobility, hypercalcemia, pathologic fracture, spinal cord. Dong-dong Cheng and Jie-lai Yang are co-first authors
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