Efficacy of levetiracetam, fosphenytoin, and valproate for established status epilpeticus by age group (ESETT): a double-blind, responsive-adaptive, randomized controlled trial

Abstract

Emergency medicine physicians are well versed in treating status epilepticus refractory to first line treatment with benzodiazepines. There are several widely accepted second line treatments for status epilepticus. It is not clear, however, which second line options might be most effective for different age groups in order to limit irreversible neuronal injury and complications secondary to metabolic and respiratory derangements.