Abstract
A hamster model was used to determine the protector capacity of vax-SPIRAL against the lethal infection after challenge with 10,000 LD of four strains isolated of a leptospirosis outbreaks in Nicaragua. These strains were 50 selected from a primary group of 16 belonging to the serogroups strains Ballum, Icterohemorragiae, Pomona, Serjoe and Pyrogenes. Most of these, except Pyrogenes serogroup, reproduced the infection in animal model and the most virulent representatives of each serogroup were selected for the challenge. The results of this study
Highlights
The results of this study suggest that vax-SPIRAL® conferred high percents of heterologous protection which aimed to consider it as a prophylactic measure useful in situations of floods and natural disasters in Nicaragua
Leptospirosis is a zoonosis caused by a large group of pathogenic Leptospira comprises about 250 serovars grouped into 20 genomic species [1]
The strains belonging to serogroups Pomona and Icterohaemorrhagiae were faced by microscopic agglutination test (MAT) to the reference monoclonal antibodies F70C7, F70C24 (L. interrogans serovar Copenhageni) and F46C5, F46C9, F58C2 (L. interrogans serovar Mozdok) respectively obtained from Leptospirosis Reference Laboratory WHO (Netherlands)
Summary
Leptospirosis is a zoonosis caused by a large group of pathogenic Leptospira comprises about 250 serovars grouped into 20 genomic species [1]. Studies on leptospirosis vaccines have focused on developing vaccine candidates based on lipopolysaccharides [5,6] lipoproteins [7,8], outer membrane proteins [9,10] and potential virulence factors [11,12]. The aim of these has been to eliminate the disadvantages of the use of inactivated/killed whole cell vaccines
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