Abstract
ObjectiveTo evaluate efficacy of denervation of the of the hip joint capsule (HJC), as a treatment of hip joint pain. Specifically, we tested the hypothesis that HJC denervation will significantly reduce the number of sensory neurons innervating the capsule.Study designDenervation of the HJC from a medial or lateral approach was followed by retrograde tracing of sensory neurons innervating the capsule.AnimalsTwenty adult male sheep (30–40 kg of body weight; Polish merino breed) were used in the study.MethodsThe hip joint was denervated from medial (n = 5) or lateral (n = 5) surgical approaches. Immediately after denervation, the retrograde neural tract tracer Fast Blue (FB) was injected into the HJC. An additional ten animals (n = 5 for medial and n = 5 for lateral approach) received the same treatment without HJC denervation to provide the appropriate controls.ResultsResults of the study revealed that the vast majority of retrogradely labelled sensory neurons innervating the HJC originate from fifth lumbar to second sacral dorsal root ganglia. Both the medial and the lateral denervations significantly reduced the number of sensory neurons innervating the HJC (39.2% and 69.0% reduction respectively).ConclusionsThese results show that denervation of the HJC is an effective surgical procedure for reduction of the sensory neuronal input to the HJC. Moreover, the lateral approach was found to be significantly more effective for reducing sensory innervation as compared to the medial one.
Highlights
Hip joint arthritis (HJA) is one of the most common orthopaedic problems in both humans and dogs
Results of the study revealed that the vast majority of retrogradely labelled sensory neurons innervating the hip joint capsule (HJC) originate from fifth lumbar to second sacral dorsal root ganglia
Both the medial and the lateral denervations significantly reduced the number of sensory neurons innervating the HJC (39.2% and 69.0% reduction respectively)
Summary
Denervation of the HJC from a medial or lateral approach was followed by retrograde tracing of sensory neurons innervating the capsule. Data Availability Statement: All relevant data are within the paper and its supporting information files. Twenty adult male sheep (30–40 kg of body weight; Polish merino breed) were used in the study
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