Efficacy of laryngeal mask airway for airway management in an experimental piglet model

Abstract

Objective To evaluate the efficacy of laryngeal mask airway (LMA) for airway management in an experimental piglet model.Methods Seventy-two male piglets,aged 2-3 months,weighing 22-32 kg,were randomly divided into 2 groups (n =36 each):tracheal intubation group (group TI) and LMA group.LMA ProSeal size 4# was placed after induction of anesthesia in group LMA.Endotracheal tube size 7.0# was placed after induction of anesthesia in group TI.Each piglet underwent 1.5 h of intermittent positive pressure ventilation.VT =8-10 ml/kg,RR =16 bpm,I∶ E =1.0∶ 1.5,FiO2 =50％,FGF =3 L/min,and partial pressure of end-tidal carbon dioxide was maintained at 35-45 mm Hg.Anesthesia was maintained with iv infusion of propofol 15 mg· kg-1·h-1 and remifentanil 40 μg· kg-1 · h-1 and intermittent iv boluses of vecuronium 0.1 mg/kg.The intubation time and success rate of intubation at first attempt were recorded.Before intubation or inserting LMA,after successful intubation or LMA placement,and immediately after removal of the endotracheal tube or LMA,SpO2 was recorded and arterial blood samples were collected for blood gas analysis.The injury to throat and flatulence were recorded.Results Compared with group TI,the intubation time was significantly shortened,and the success rate of intubation at first attempt,SpO2 and PaO2 were increased,and the incidence of injury to throat and PaCO2 were decreased in LMA group (P ＜ 0.05).SpO2 was ＞ 95％ and PaO2 ＞ 150 mm Hg during ventilation in both groups.Conclusion The LMA ProSeal can provide adequate ventilation with fewer complications and can be conveniently,safely and effectively used in an experimental piglet model. Key words: Laryngeal masks; Intubation, intratracheal; Respiration, artificial