Abstract
AimTo assess the effect of Lactobacillus supplementation on Helicobacter pylori eradication rates and side effects of the triple therapy.MethodsPubMed, Embase, Web of Science and Cochrane Library were searched for articles published up to July, 2019. Review Manager 5.3 and Stata 12.0 were used for statistical analyses.ResultsThe initial database search resulted in 852 articles. Through exclusion and screening, 11 randomized controlled trials involving a total of 724 patients were finally included in this meta-analysis. The H. pylori elimination rate in the Lactobacillus supplement group was significantly higher than that in the control group (RR 1.16, 95% CI 1.08–1.25, P<0.0001). Subgroup analysis showed that the eradication rates were significantly enhanced in both adults and children group, and no significant difference was detected between Asia and Europe group. In addition, sub-analysis based on duration of Lactobacillus supplementation showed the pooled RRs in the long-term and short-term groups were 1.17 (95%CI 1.06–1.30) and 1.16 (95% CI 1.04–1.30), respectively. Regarding the Lactobacillus strains, the pooled RR was 1.33 (95% CI 1.10–1.62) in the L. casei group, 1.18 (95% CI 1.03–1.34) in the L. reuteri group while 1.02 (95% CI 0.87–1.21) in the Lactobacillus GG group. As for the total side effects, Lactobacillus supplementation significantly reduced the incidence of taste disturbance (RR = 0.36, 95% CI 0.17–0.74, P = 0.005).ConclusionsLactobacillus supplementation during the treatment of Helicobacter pylori infection can effectively improve the eradication rates, and reduce the incidence of therapy-related taste disturbance.
Highlights
Helicobacter pylori, a microaerophilic gram-negative bacterium, has quickly gained widespread attention since its discovery
Sub-analysis based on duration of Lactobacillus supplementation showed the pooled relative risk (RR) in the long-term and short-term groups were 1.17 (95%confidence interval (CI) 1.06–1.30) and 1.16, respectively
Regarding the Lactobacillus strains, the pooled RR was 1.33 in the L. casei group, 1.18 in the L. reuteri group while 1.02 in the Lactobacillus GG group
Summary
To assess the effect of Lactobacillus supplementation on Helicobacter pylori eradication rates and side effects of the triple therapy. Editor: Rosa del Campo, Instiuto Ramon y Cajal de Investigacion Sanitaria (IRYCIS), SPAIN. Data Availability Statement: All relevant data are within the manuscript and its Supporting Information files. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript
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