Abstract
In view of the gastrointestinal problems generated by the ketoprofen use, the ketoprofen association with omeprazole is available on the market. However, this association efficacy in acute pain control has not been established. Bilateral extraction of lower third molars in similar positions is currently the most used model for the evaluation and investigation of the efficacy and pharmacological effects of new compounds for the treatment of acute postoperative pain. The randomized and crossover study consisted in evaluating the clinical efficacy of therapy performed by ketoprofen 100 mg (twice daily-b.i.d.) versus ketoprofen 200 mg + omeprazole 20 mg (once daily-q.d.) to pain, swelling and trismus control in the bilateral extraction model of lower third molars in similar positions in two different appointments, in 50 volunteers. Volunteers reported significantly less postoperative pain at various post-operative periods and consumed less rescue analgesic medication (acetaminophen 750 mg) throughout the study when they took the combination of ketoprofen 200 mg + omeprazole 20 mg (q.d.). Following administration of both study drugs, no gastrointestinal adverse reactions were reported by volunteers. Furthermore, the evaluations of the drugs in pain control by the volunteers were significantly favorable to ketoprofen 200 mg + omeprazole 20 mg (q.d.). For swelling and trismus control, the treatments presented similar results. In conclusion, when volunteers took ketoprofen 200 mg + omeprazole 20 mg (q.d.), they reported significantly less postoperative pain at various post-surgical periods and consumed less rescue analgesic medication throughout the study compared with ketoprofen 100 mg (b.i.d).
Highlights
Bilateral extraction of lower third molars in similar positions is currently the most used model for the evaluation and investigation of the efficacy and pharmacological effects of new compounds for the treatment of postoperative pain, such as analgesics and anti-inflammatory drugs [1,2]
When volunteers took ketoprofen 200 mg + omeprazole 20 mg q.d., osteotomies and tooth sectioning were performed in 30 surgeries, only osteotomies in 12 surgeries, and 9 did not require osteotomies and tooth sectioning
The present randomized and cross-over study investigated the clinical efficacy of postoperative pain control, swelling, and trismus using enterally ketoprofen 100 mg once every 12 h and ketoprofen 200 mg in combination with omeprazole 20 mg administered once every 24 h, after extractions of lower third molars under local anesthesia
Summary
Bilateral extraction of lower third molars in similar positions is currently the most used model for the evaluation and investigation of the efficacy and pharmacological effects of new compounds for the treatment of postoperative pain, such as analgesics and anti-inflammatory drugs [1,2]. This type of surgical procedure is recommended since some tissues are manipulated and traumatized in the region where the extraction is performed, composed mainly of loose connective tissue that contains blood and lymphatic vessels. In addition to these procedures, non-steroidal anti-inflammatory drugs (NSAIDs) have been extensively used as adjuvants for the reduction of these postoperative complications derived from the extractions of the lower third molars [1,2,8,9]
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