Efficacy of Kanglaite injection combined with chemotherapy for the treatment of hepatocellular carcinoma and its effect on immune system

Abstract

Objective This study aims to discuss the efficacy of Kanglaite injection combined with chemotherapy on hepatocellular carcinoma (HCC) and its effect on immune system. Methods 86 patients with HCC were selected.They were randomly divided into two groups.The control group was given chemotherapy.The observation group was given chemotherapy combined with Kanglaite injection.And according to the indicators of liver function, immune function, and Karnofsky performance status (KPS) scores before and after chemotherapy, this study evaluated the efficacy of Kanglaite injection combined with chemotherapy on hepatocellular carcinoma (HCC) and its effect on immune system. Results After chemotherapy, the effective rate of observation group was higher than that of the control group(P 0.05). After chemotherapy, the ALT, AST and GGT were increased in both groups, and the elevated levels of control group was higher (P 0.05). After chemotherapy, the quantity of CD3, CD4, and CD4/CD8 was increased in both groups (P 0.05), and after chemotherapy, KPS scores were increased in both groups, the scores of the observation group were higher than that of the control group (P<0.05). Conclusion Kanglaite injection combined with chemotherapy had a better curative effect on HCC.It improved the immunity of patients and the quality of life with little damage to liver function.Kanglaite might be a good option as an adjuvant therapy for patients with HCC. Key words: Kanglaite injection; Chemotherapy; Hepatocellular carcinoma; Immunity