Abstract
BackgroundHerbal combination of Itrifal Saghir (triphala) has been widely used in traditional medicine. And brings health benefits such as antioxidant effect and scavenger of hydroxyl radicals and nitric oxide radicals activity and substantiated in traditional medicine a anti-obesity.Material and methodIn this study we aimed to assess the efficacy of this herbal medicinal on reduction of weight and body mass index (BMI) of simple obese subjects in comparison with placebo. Obese subjects aged between 16 and 60 years were selected for 12-week, double-blind, randomized, placebo-controlled trial using a parallel design. Subjects were randomly assigned to take 5 grams of either the Itrifal Saghir (n = 31) or placebo (n = 31), 2 times daily for 12 weeks. Measures of body weight, BMI, waist circumference (WC), hip circumference (HC), were assessed at baseline and once every four weeks during the 12 week treatment period. The safety was evaluated by means of measuring the liver and kidney function. Homeostasis model of insulin resistance (HOMA-IR) was calculated as [fasting insulin (μU/mL) × fasting glucose (mmol/L)/22.5].ResultsCompared to placebo group, in treatment group the mean difference of effective weight loss was 4.82Kg (CI95% 3.52 - 6.11, ρ < 0.001), the mean of decrease in waist circumference was 4.01 cm (CI 95% 2.13 - 5.90, ρ < 0.001), and the mean decrease in hip circumference was 3. 21 cm (CI 95% 1.96 - 4.45, ρ < 0.001) in treated subjects. No adverse effects or significant changes in liver and kidney function tests were observed in both placebo and treated groups.ConclusionsItrifal Saghir appears to produce a positive effect on weight loss in obese subjects.
Highlights
Herbal combination of Itrifal Saghir has been widely used in traditional medicine
Itrifal Saghir appears to produce a positive effect on weight loss in obese subjects
Obesity is recognized as an important metabolic disorder and a major public health issue which affects a large number of people around the world
Summary
Herbal combination of Itrifal Saghir (triphala) has been widely used in traditional medicine. Brings health benefits such as antioxidant effect and scavenger of hydroxyl radicals and nitric oxide radicals activity and substantiated in traditional medicine a anti-obesity. Many herbal medicinal products have been used for several decades or even hundreds of years One of this traditional products, Itrifal Saghir (etrifel saqir) or atrifal arabized of Triphala [16] is a polyherbal preparation that has been marketed in Iran for a several years. It composed of the three medicinal fruits Phyllanthus emblica L. or Emblica officinalis Gaertn. We aimed to conduct a randomized, placebo-controlled clinical trial to evaluate the weight reducing effects and safety of 3 months consumption of commonly used dose of Itrifal Saghir (10 g/day) in healthy adult subjects being on a typical Iranian diet
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