Efficacy of intralesional 5 Fluorouracil, triamcinolone acetonide and CO2 laser for treatment of keloids and hypertrophic scars- A comparative study

Abstract

Background: Effective keloid management is still a distant dream in spite of many recent modalities being tried for the same.Objective: To compare the efficacy of intralesional 5-Fluorouracil, intralesional triamcinolone acetonide and CO2 laser in the treatment of keloids. Materials andMethods: This randomized controlled trial was conducted on 45 patients with keloids, randomly divided into three groups, treated with intralesional 5-fluorouracil (Group A), CO2 laser (Group B) and triamcinolone acetonide (Group C). The groups were compared for reduction in the size of keloid, symptoms (pain and itching) and the incidence of adverse effects.Results: The reduction in the size of the keloid was found to be significantly better in Group A (86.33%) than in Group B (80%) and in Group C (66.66%).Conclusion: Reduction in the size of the keloid was significantly better in those treated with 5-fluorouracil than those treated with triamcinolone acetonide and CO2 laser. The incidence of adverse effects like immediate burning sensation, ulceration are more with intralesional 5-fluorouracil. The incidence of recurrence was higher with CO laser than the other modalities.