Efficacy of Intra-articular Injection of Simvastatin in Treatment of Internal Derangement of Temporomandibular Joint.

Abstract

ABSTRACTIntroduction :ID management is one of challenges in maxillofacial filed. Almost80% of adult symptomatic patients with TMD have some form of ID (1). Data fromrelated literature has suggested that arthrocentesis may be of some benefit to managesymptoms of TMDs. Such a technique was first introduced for the management ofsudden onset of closed lockAim : This study aimed to evaluate efficacy of simvastatin intra-articular injectionin management of internal derangement (ID) of temporomandibular joint ( TMJ).Patients and methods: 15 patients with internal TMJ derangement were included in thisstudy. All patients were subjected to preoperative clinical examination and preoperativemagnetic resonance imaging (MRI) for the affected joints. The affected joints treatedwith arthrocentesis followed by intra-articular injection of 1ml. simvastatin twice amonth. Clinical follow up were done at 24 hours post- operatively, one week, one monthand six months. Then, after six months MRI was repeated to compare with preoperativeimages. Results: Patients showed better results in comparison to preoperativeparameters at 1 week, 4 and 24 weeks intervals. Patients showed better MRI findings incomparison to preoperative findings where position of the disc was almost returned toits normal anatomical position. Conclusion: Simvastatin intra-articular injection afterarthrocentesis