Efficacy of internal and external teat sealants on cure and new infection risk in dry-off protocols for Holstein cows

Abstract

Internal teat sealant products have been used alone or in combination with antibiotic dry cow treatment to prevent new IMI over the dry period in dairy cows. Conversely, knowledge about the efficacy of external teat sealants in the prevention of IMI is scarce. The objective of our study was to investigate the effect of 2 different teat sealants, one internal teat sealant and one external teat sealant, on the (1) risk of new IMI during the dry period, (2) risk of IMI cure, (3) first test day linear somatic cell score, (4) first test day milk yield, (5) incidence of farm-diagnosed clinical mastitis ≤ 30 DIM, and (6) incidence of culling ≤ 30 DIM. In a randomized clinical trial, Holstein cows (n = 1,500) from one commercial dairy were assigned to treatment and control groups. At dry off, cows in the treatment groups received an antibiotic dry cow treatment in combination with either an internal teat sealant (INT) or a single application of an external teat sealant (EXT). Control (CON) cows received the antibiotic dry cow treatment alone. Data on linear somatic cell score from the last DHI test day before dry off and the first test after calving, first test day milk yield, and the occurrence of farm-diagnosed clinical mastitis and culling ≤ 30 DIM were obtained from the farm management program. New IMI and cure of IMI during the dry period were calculated. Linear somatic cell score (mean ± SD) at first test day after calving differed among groups and was 3.2 ± 2.2 in CON, 2.8 ± 2.0 in INT, and 3.0 ± 2.1 in EXT groups. The risk of new IMI differed among groups and was 30.2% for CON cows, 18.2% for INT cows, and 22.6% for EXT cows. A Poisson regression analysis revealed that, compared with CON cows, the risks of new IMI were 40% lower for INT cows (risk ratio (RR) = 0.60, 95% CI = 0.41 to 0.88) and 25% lower for EXT cows (RR = 0.75, 95% CI = 0.52 to 1.07). By contrast, no meaningful differences were documented for cure risk, clinical mastitis risk during the first 30 DIM, or culling risk within the first 30 DIM. In summary, cows dried off with an INT in combination with antibiotic dry cow treatment had a lower linear somatic cell score at first test day after calving and reduced risk of new IMI than cows dried off with an EXT in addition to antibiotic dry cow treatment or cows dried off using antibiotic dry cow treatment alone. Further, we found supporting evidence that cows dried off with an EXT in addition to antibiotic dry cow treatment might have an advantage in reduced new IMI over cows dried off with an antibiotic dry cow treatment alone.