Efficacy of Intense Pulsed Light Combined Blood Extract Eye Drops for Treatment of Nociceptive Pain in Dry Eye Patients.

Yaying Wu,Lin Lin,Yanan Huo,Yu Han,Yirui Zhu,Xiaodan Huang,Yujie Mou,Yu Zhang,Shuo Yang

doi:10.3390/jcm11051312

Abstract

Purpose: To investigate the efficacy of intense pulsed light (IPL) combined with deproteinized calf blood extract (DCBE) eye drops for dry eye disease (DED) patients with nociceptive ocular pain. Methods: In this prospective, one-center, interventional study, 23 subjects with DED and ocular pain were treated with a combination of IPL and DCBE eye drops for four sessions at a four-week interval. Subjective and objective assessments on nociceptive pain and dry eye were examined and analyzed. Results: The visual analog scale (VAS), ocular surface disease index, ocular pain assessment survey (OPAS), patient health questionnaire-9 items, generalized anxiety disorder (GAD-7), Athens insomnia scale, corneal fluorescein staining score, meibomian gland secretion quality, and expressibility scores were significantly reduced after the treatment. Tear break-up time and Schirmer I test increased significantly. The brand density of corneal nerves and neuropeptide substance P also significantly increased. OPAS, GAD-7, meibomian gland secretion quality, and expressibility scores were essential factors affecting the VAS changes. Conclusions: IPL combined with DCBE drop therapy was effective for DED patients with ocular pain. With such treatment, both DED symptoms and the sensation of ocular pain may be improved.

Highlights

Dry eye disease (DED) is considered a complicated and multifactorial disorder of the ocular surface, with the prevalence ranging from 5 to 50% in individuals worldwide [1].According to the International Dry Eye Workshop (2017), DED was defined as “a multifactorial disease of the ocular surface characterized by a loss of homeostasis of the tear film and accompanied by ocular symptoms, in which tear film instability and hyperosmolarity, ocular surface inflammation and damage, and neurosensory abnormalities play etiological roles” [2]
Our study was the first to investigate the effectiveness of a combination treatment of intense pulsed light (IPL) and deproteinized calf blood extract (DCBE) eye drops on DED accompanied by ocular pain
We found that IPL combined with DCBE eye drops for four sessions was an effective treatment to relieve ocular pain in DED patients

Summary

Introduction

Dry eye disease (DED) is considered a complicated and multifactorial disorder of the ocular surface, with the prevalence ranging from 5 to 50% in individuals worldwide [1]. According to the International Dry Eye Workshop (2017), DED was defined as “a multifactorial disease of the ocular surface characterized by a loss of homeostasis of the tear film and accompanied by ocular symptoms, in which tear film instability and hyperosmolarity, ocular surface inflammation and damage, and neurosensory abnormalities play etiological roles” [2]. Several typical clinical symptoms are encompassed by DED, including the sensation of eye dryness, irritation, burning, soreness, and ocular pain [4–6]. The homeostasis of the ocular surface is broken by DED, damaging neuron nociceptors and peripheral nerves in the cornea and conjunctiva will result in nociceptive pain [9]. Meibomian gland dysfunction (MGD) is regarded as a sub-type of evaporative

Methods

Results

Conclusion