Abstract
Background And Objectives: Corticosteroids have a role in increasingthe reabsorption of lung fluids. Hence, this study wasconductedto assess efficacyandsafetyofinhaledBudesonideinreducingtheneedforrespiratorysupport,clinicalimprovement, time to reach full feeds and duration of hospital stay in neonates withTTN. Materials And Methods: 100 Neonates(>35weeks), diagnosed as TTNwere included in study andrandomized into 2 groups-study and control groups. Allthe neonates were managed as per existing NICU protocol. Along with standardsupportivemanagementincludingrespiratorysupport,theyreceivedfollowingnebulizationwith6hoursand12hoursafterthat. Intervention: Studygroup:Budesonidenebulization(2ml=1000ug) Controlgroup:Placebo(0.9%Normalsalinesolution2ml) Baselinedemographicandclinicalprofile,clinicalparametersat4,12,24and48hoursafter intervention, requirement of respiratory support, duration of hospital stay andadverseeventswererecorded,comparedandanalyzedinbothgroups. Results: Improvement in Budesonide group was significantly better in regard torespiratoryrate,Downescore(P<0.000),andoxygensaturation(P<0.000)at4hours,12 hours, 24 hours and 48hour. The total duration of mean respiratory support instudygroup(13.8hours)wassignificantlylowerthanplacebogroup(32.52hours)andwasstatisticallysignificant(p<0.000).TherewassignificantdifferenceindurationofNICUstay(2.50±1.055vs3.86±1.088days,p<0.05)andoccurrenceofnosocomialinfection among study and control group. No significant adverse events related tosteroidinhalationwereobserved. Conclusion: The early inhaled corticosteroid (budesonide) in TTN improved theclinicalcourseofTTN,withreduceddurationofrespiratorysupportandhospitalstay,withoutanysignificantsideeffects. InconclusioninhaledbudesonidecanbeusedasaoptioninmanagementofTTNinlatepretermandtermneonates.
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