Abstract
The results of the open controlled prospective clinical and immunological trial indicate that including of pidotimod into the complex therapy of pyelonephritis in children (n=30) lead to reliable decrease of recurrence risk and frequency during 6 months after treatment withdrawal in comparison with children receiving antibacterial monotherapy (n=20). The duration of etiotropic treatment for arresting of the active manifestations of urinary tract infection was lower in patients who were administered the afore-mentioned drug. Immunological monitoring of the urine cytokine status during pidotimod treatment showed that there were signs of T helper 1 cells activation predominance (increase in interferon/interleukin 10 ratio), as well as decrease in granulocyte macrophage colony-stimulating factor concentration, which seems to cause the delayed influence of the drug on the course of urinary tract infection.
Highlights
50 детей с пиелонефритом (6 мальчиков и 44 девочки), которые были разделены на основную группу (в схему лечения был включен пидотимод) и группу сравнения
Patients and methods: 50 children with pyelonephritis (6 boys and 44 girls) were included into the study and divided into 2 groups — the main group and comparison group
Diagnosis of pyelonephritis was based on the criteria developed by L
Summary
Эффективность иммунокоррекции с помощью синтетического дипептида при пиелонефрите у детей. Цель исследования: оценить терапевтическую эффективность и влияние пидотимода на мочевые концентрации цитокинов при пиелонефрите у детей. Получавших данный препарат, сокращалась продолжительность и длительность этиотропной терапии для купирования активных проявлений мочевой инфекции. Выводы: исследование позволило установить благоприятное влияние пидотимода в сочетании с этиотропной терапией на течение пиелонефрита у детей (главным образом — в отдаленные сроки наблюдения). Применение иммунотропных лекарственных средств при инфекциях мочевой системы у детей имеет достаточно большую, почти 40-летнюю историю — с момента, когда Н. Patients and methods: 50 children with pyelonephritis (6 boys and 44 girls) were included into the study and divided into 2 groups — the main group (with pidotimod introducing into the treatment scheme) and comparison group. Цель исследования: оценить терапевтическую детей и/или опроса по телефону родителей о состоянии эффективность и влияние пидотимода на мочевые кон- здоровья пациентов и результатах анализов мочи.
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