Abstract
Colorectal cancer (CRC) continues to be a leading cause of mortality and morbidity in the United States. Cancer chemoprevention—the use of specific pharmacologic agents or nutrients to prevent, reverse, or inhibit the process of carcinogenesis—is an attractive approach. The cancer chemopreventive potential of herbs has been of great interest, in part because it has been reported that about one third of the US population regularly consumes one or more herbal supplements. This review describes the CRC chemopreventive effects of herbal products identified by the National Health Interview Survey to be the most widely consumed in the United States. This report summarizes published studies of chemopreventive and cytotoxic effects of herbs in human colon cancer cells, proposed molecular mechanisms, efficacy studies using in vivo CRC models, and epidemiologic studies.
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