Efficacy of grape seed extract gel in the treatment of chronic periodontitis: A randomized clinical study.

Abstract

The aim of the present study was to assess the effectiveness of applying grape seed extract (GSE) gel in periodontal pockets for the treatment of chronic periodontitis. Eighty-six sites with pocket depth (PD) >4mm were selected from five systemically-healthy patients in whom scaling, and root planing were performed, and oral instructions were given, a week earlier. PD, gingival index (GI), plaque index (PI), and bleeding on probing (BOP) were measured, and sites were then divided into the control group (N=38) and GSE group (N=48). Four doses of formulated 2% mucoadhesive GSE gel were applied to GSE group sites at baseline visit (T0), and 3, 6, and 9days after T0. Similarly, a control gel was applied to the control sites. PD, PI, GI and BOP were re-evaluated after 4weeks and 6months of first gel application. Paired t test for both the control and GSE groups showed a significant reduction for all variables after 6months of gel application (P<.05). The independent t test showed a significant difference (P<.05) only in the reduction of gingival index (mean: 0.85±0.77 for control and 1.3±0.8 for GSE) and plaque index (mean: 0.75±0.71 for control and 1.12±0.7 for GSE). The subgingival application of the formulated 2% mucoadhesive GSE gel showed significant improvement in the PI and GI only.