Abstract
BackgroundFrog skin has been sequentially and scientifically evaluated by our group for its wound healing efficiency. Owing to the complex structure of skin, attempts were being made to analyse the role of individual constituents in different phases of healing. Our earlier papers have shown the significance of frog skin not only in wound healing but also enhancing the proliferating activity of the epidermal and dermal cells which are instrumental for normal healing process. We also have identified for the first time novel antimicrobial peptides from the skin of Rana tigerina and thereby reduce the complications involved in the sepsis.Purpose of the study and ResultsThe current study envisages the role of frog skin lipids in the inflammatory phase of wound healing. The lipid moiety of the frog skin dominated by phospholipids exhibited a dose dependent acceleration of healing irrespective of the mode of application. The efficiency of the extract is attributed partially to the anti-inflammatory activity as observed by the histochemical and immunostimulatory together with plethysmographic studies.ConclusionsThus, frog skin for the first time has been demonstrated to possess lipid components with pharmaceutical and therapeutic potential. The identification and characterization of such natural healing molecules and evaluating their mechanism of action would therefore provide basis for understanding the cues of Nature and hence can be used for application in medicine.
Highlights
Frog skin has been sequentially and scientifically evaluated by our group for its wound healing efficiency
Four broad spectrum 11 and 12 residue novel antimicrobial peptides coined tigerinins have been already isolated by Purna Sai et al, [2] and Sitaram et al, [3] from the adrenalin stimulated skin secretions of the Indian frog Rana tigerina
Oedema induced by carrageenan is a model of exudate inflammation and agents effective in decreasing carrageenan induced oedema can be used as anti-inflammatory agents in acute inflammation
Summary
Frog skin has been sequentially and scientifically evaluated by our group for its wound healing efficiency. Owing to the complex structure of skin, attempts were being made to analyse the role of individual constituents in different phases of healing. Purpose of the study and Results: The current study envisages the role of frog skin lipids in the inflammatory phase of wound healing. The purification and characterization of the individual constituents of the frog skin and understanding the mechanism of biological activity has been attempted in a sequential manner. Four broad spectrum 11 and 12 residue novel antimicrobial peptides coined tigerinins have been already isolated by Purna Sai et al, [2] and Sitaram et al, [3] from the adrenalin stimulated skin secretions of the Indian frog Rana tigerina.
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