Abstract
Background: Acne scars are most distressing sequelae of acne vulgaris having a major impact on psychosocial aspect and quality of life of an individual. In spite of various therapeutic modalities available treatment of acne scars is challenging. Resurfacing techniques such as Fractional Co2 Laser is a well-established treatment option for acne scar. Platelet-Rich Plasma (PRP), an autologous preparation of growth factors helps in wound healing and tissue regeneration.
 Aim: To study the efficacy of Fractional CO2 Laser with Topical Platelet-Rich Plasma in Acne scars.
 Materials and Methods: A total of 15 patients with atrophic facial acne scar, aged 18-40 years attending Outpatient Department of Dermatology, Venereology and Leprosy at tertiary care centre during January 2019 to December 2019 were included for this interventional study after written informed consent. The patients underwent six sessions of Fractional CO2 Laser with Topical application of Platelet-Rich Plasma at monthly intervals. Pre and post treatment comparative Goodman and Baron’s quantitative global scarring grading and patients self-assessment score were used for assessment.
 Results: At the end of study mild reduction in Goodman and Baron’s quantitative score for acne scar was noted in 13 patients (86.6%). Mean Goodman and Baron’s quantitative score att 4 weeks after sixth sitting was 13.13 ± 4.60. On patients self-assessment moderate resolution of acne scar was noted in 8 patients (53.3%).
 Conclusion: Fractional CO2 Laser with Topical Platelet-Rich Plasma application has mild to moderate improvement of acne scars and shorter down time of Fractional CO2 Laser.
 Keywords: Acne scar, Fractional Co2 Laser, Topical Platelet-Rich Plasma
Highlights
The prevalence of acne scarring is estimated to be between 1% and 11% in the general population, with scarring affecting the face in most of the cases. [1,2] Acne scars are result of compromised collagen production during the natural wound healing process, causing topographical depressions.[3]
The mean baseline Goodman and Baron’s quantitative score was 16.13 ± 4.52 and mean final Goodman and Baron’s quantitative score was 13.13 ± 4.60.(Figure 2) Mild reduction in Goodman and Baron’s quantitative score was noted in 13 (86.6%) patients while 2 (13.3%) patients had moderate reduction in Goodman and Baron’s quantitative score after the final session.(Table 1) (Figures 3-6) On patient self-assessment of scars after 4 weeks of final session mild resolution was noted by 6 (40%) patients, moderate resolution by 8 (53.3%) patients and good resolution by 1(6.6%) patient.(Figure 7) No undesired or any adverse effects were noted
In our study moderate resolution of acne scar was noted by patients on self-assessment which indicates that patients were satisfied with the treatment outcome
Summary
The prevalence of acne scarring is estimated to be between 1% and 11% in the general population, with scarring affecting the face in most of the cases. [1,2] Acne scars are result of compromised collagen production during the natural wound healing process, causing topographical depressions.[3]. Combination of therapeutic modalities in treatment of acne scars sequentially or rotationally may help to improve outcome and minimize side-effects. With this background an interventional study was undertaken to assess the efficacy of fractional CO2 laser with topical platelet rich plasma in treatment of acne scars. In spite of various therapeutic modalities available treatment of acne scars is challenging Resurfacing techniques such as Fractional Co2 Laser is a well-established treatment option for acne scar. Aim: To study the efficacy of Fractional CO2 Laser with Topical Platelet-Rich Plasma in Acne scars. Results: At the end of study mild reduction in Goodman and Baron’s quantitative score for acne scar was noted in 13 patients (86.6%).
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