Abstract
BackgroundThe efficacy of fluralaner spot-on solution administered once topically against induced infestations with Rhipicephalus sanguineus was evaluated in dogs over a 12-week post-treatment period.MethodsSix negative-controlled studies were conducted, involving a total of 112 adult dogs (57 mixed breed, 47 Beagles, eight Labradors). In each study, dogs were randomized to two groups of eight to ten dogs each. On day 0, dogs in each treated group were topically administered fluralaner spot-on solution once at a dose of 25 mg/kg body weight, while dogs in each control group were not treated. Two days before treatment, and on days 28, 56 and 84 after treatment, all dogs were infested with approximately 50 unfed, adult Rh. sanguineus ticks (sex ratio 1:1). Ticks were removed and counted on days 2, 30 (4 weeks), 58 (8 weeks), and 86 (12 weeks) after treatment to assess efficacy.ResultsEfficacy against ticks 2 days after treatment was 91.1 % (study 1), 98.4 % (study 2), 100 % (study 3), 97.6 % (study 4), 99.6 % (study 5), and 99.8 % (study 6). At all other assessment time points, tick efficacy was 95.4–100 %. Tick reduction in all treatment groups was significant at all assessment time points (P < 0.0001).ConclusionsA single topical administration of fluralaner spot-on solution provides a high level of therapeutic and persistent efficacy against Rh. sanguineus ticks over the subsequent 12 weeks.
Highlights
The efficacy of fluralaner spot-on solution administered once topically against induced infestations with Rhipicephalus sanguineus was evaluated in dogs over a 12-week post-treatment period
Rhipicephalus sanguineus ticks can even overwinter in the environment and infest dogs during winter in some regions of temperate climate [6]
This paper summarizes the results of six independent studies, which evaluated the efficacy of fluralaner spot-on solution against Rh. sanguineus ticks over a 12-week posttreatment period
Summary
The efficacy of fluralaner spot-on solution administered once topically against induced infestations with Rhipicephalus sanguineus was evaluated in dogs over a 12-week post-treatment period. Rhipicephalus sanguineus, the brown dog tick, is the most widespread tick worldwide [1]. Rhipicephalus sanguineus ticks can attach everywhere on the dog, but the head ( the ears), interdigital spaces, back, inguinal region and axilla are among their preferred attachment sites [6]. Rhipicephalus sanguineus ticks can even overwinter in the environment and infest dogs during winter in some regions of temperate climate (e.g. southeastern Oklahoma and northwestern Arkansas, United States) [6]. As known vectors of pathogen transmission as well as a cause of discomfort and blood loss for dogs, ticks and tick infestations are a serious concern for owners. Control of Rh. sanguineus is of great medical and veterinary importance
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