Abstract
Objective: To identify efficacy of fetal stem cells in treatment of the patients suffering from Type 2 diabetes mellitus in presence of insulin resistance and to summarize all characteristics of post-transplantation disease course. Materials and methods: 42 patients suffering from Type 2 diabetes mellitus (T2DM) in presence of insulin resistance were examined including 27 men and 15 women. Glycaemia ranges were controlled by diet therapy in 7 patients (16.7%), whereas the rest of the patients were recommended antihyperglycemic medicines (biguanides, thiazolidinediones, sulfonylurea derivatives and α-reductase inhibitors). Fetal stem cells (FSCs) were administered in complex therapy for the patients with T2DM and the data of clinical, laboratory and anthropometric investigations were analyzed over the study period. Results: Positive effects to values of carbohydrate and lipid metabolism, as well as arterial blood pressure (ABP) in T2DM have been justified. FSCs capacity to decreasing insulin resistance (in accordance with the HOMA-IR scale) which results in stable continuous diabetes mellitus compensation was established. Conclusion: FSCs use in complex treatment of patients with T2DM stabilizes disease compensation and leads to decrease in hyperinsulinemia and lower insulin resistance.
Highlights
Diabetes mellitus (DM) is a markedly spread endocrine illness worldwide, which has already grown into a non-infectious epidemic
Fetal stem cells (FSCs) capacity to decreasing insulin resistance which results in stable continuous diabetes mellitus compensation was established
FSCs use in complex treatment of patients with Type 2 diabetes mellitus (T2DM) stabilizes disease compensation and leads to decrease in hyperinsulinemia and lower insulin resistance
Summary
Diabetes mellitus (DM) is a markedly spread endocrine illness worldwide, which has already grown into a non-infectious epidemic. As far as often DM disease cannot be diagnosed over the years due to lack of hyperglycemia symptoms – subsequently, the patients would often suffer 1-2 disease complications prior to T2DM diagnosis could be confirmed in the patient [4]. 80% of the patients with T2DM are suffering from arterial hypertension – their life span is threefold lower compared to this disease prevalence among the healthy population. Spread of ischemic heart disease (IHD) along with associated T2DM illness is 2-4 times more frequent among the patients; the risk of acute myocardial infarction increases 6-10 times and acute disturbances of cerebral circulation – are 4-7-fold more often in comparison with the same problems in the patients without DM [5,6]
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