Abstract
BACKGROUND: Contractility of the myometrium is usually diminished during pregnancy to accommodate and protect the growing products of conception; drugs like Hyoscine butylbromide and Drotaverine are used to shorten the duration of labor in many hospitals all over the world.
 OBJECTIVE: To compare the effect of intravenous Drotaverine and Hyoscine Butylbromide rectal suppository on duration of labour and rate of cervical dilatation.
 METHODS: Three hundred pregnant women with term pregnancy in active labour were selected by simple randomization and were divided into three groups: Group A, where injection Drotaverine intravenous was given; Group B, where Hyoscine Butylbromide rectal suppository was instilled; and in Group C, where no drug was given.
 RESULTS: Mean duration of first stage of labour was 179.1 min, 159.3 min and 299.0 min in groups A, B and C, respectively. Rate of cervical dilatation in groups A, B and C was 2.6, 2.9 and 2.0 cm/hr, respectively. Most of the subjects delivered vaginally. No serious side effects were noted in both the drug groups.
 CONCLUSION: Hyoscine Butylbromide is more effective than Drotaverine in reducing the duration of active phase of labour. There is a significant improvement in the rate of cervical dilatation with Hyoscine Butylbromide when compared to Drotaverine. JMS 2012;15(1):39-43.
Highlights
Contractility of the myometrium is usually diminished during pregnancy to accommodate and protect the growing products of conception; drugs like Hyoscine butylbromide and Drotaverine are used to shorten the duration of labor in many hospitals all over the world
The duration of first stage of labour in the Drotaverine group was lesser than the control group and was statistically significant
The rate of cervical dilatation in the Drotaverine group was statistically higher than the control group
Summary
Contractility of the myometrium is usually diminished during pregnancy to accommodate and protect the growing products of conception; drugs like Hyoscine butylbromide and Drotaverine are used to shorten the duration of labor in many hospitals all over the world. OBJECTIVE: To compare the effect of intravenous Drotaverine and Hyoscine Butylbromide rectal suppository on duration of labour and rate of cervical dilatation. METHODS: Three hundred pregnant women with term pregnancy in active labour were selected by simple randomization and were divided into three groups: Group A, where injection Drotaverine intravenous was given; Group B, where Hyoscine Butylbromide rectal suppository was instilled; and in Group C, where no drug was given. RESULTS: Mean duration of first stage of labour was 179.1 min, 159.3 min and 299.0 min in groups A, B and C, respectively. Rate of cervical dilatation in groups A, B and C was 2.6, 2.9 and 2.0 cm/hr, respectively. There is a significant improvement in the rate of cervical dilatation with Hyoscine Butylbromide when compared to Drotaverine.
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