Efficacy of different doses of oxycodone for prevention of fentanyl-induced cough during induction of general anesthesia

Abstract

Objective To evaluate the efficacy of different doses of oxycodone for prevention of fentanyl-induced cough during induction of general anesthesia. Methods A total of 250 American Society of Anesthesiologists physical statusⅠor Ⅱ patients of both sexes, aged 22-62 yr, weighing 47-81 kg, undergoing elective surgery, were divided into 5 groups (n=50 each) using a random number table method: different doses of oxycodone groups (O1-4 groups) and control group (group C). Oxycodone 0.025, 0.050, 0.075 and 0.100 mg/kg were intravenously injected in O1-4 groups, respectively, while the equal volume of normal saline was given instead of oxycodone in group C. Five minutes later fentanyl 3 μg/kg was intravenously injected within 5 s, and then 2 min later the other drugs were administered for induction.The occurrence and severity of cough were observed within 2 min after fentanyl injection.The development of respiratory depression and hypotension and severe bradycardia during induction of anesthesia were recorded within 5 min after oxycodone injection. Results The incidence of cough was significantly lower in O1-4 groups than in group C (P 0.05). No respiratory depression was found in C and O1-3 groups.The incidence of respiratory depression was significantly higher in group O4 than in C and O1-3 groups(P 0.05). Conclusion Oxycodone 0.025 mg/kg provides better efficacy in preventing fentanyl-induced cough during induction of general anesthesia. Key words: Oxycodone; Fentanyl; Cough