Abstract

Introduction: Periodontitis is the most common cause for tooth loss in adults and advanced types affect 10–15% of adults worldwide. The attempts to save tooth and regenerate periodontal apparatus including cementum, periodontal ligament and alveolar bone reach to the dental tissue derived stem cell therapy. Although there have been several periodontitis models suggested, apical involvement of tooth root is especially challenging to be regenerated and various dental stem cell therapy for the state has never been investigated.

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