Abstract

Objective To investigate the therapeutic effect of dendritic cells (DC)-cytokine guided killer cells (CIK) combined with interferon-γ (IFN-γ) on chronic viral hepatitis type B. Methods Autologous peripheral blood was extracted from the patients to culture autologous DC-CIK. Hepatitis B virus surface antigen (HBsAg) was activated and then returned into chronic viral hepatitis type B patients. At the same time, IFN-γ was given for 48 weeks by subcutaneous injection. The levels of hepatitis B virus-DNA (HBV-DNA) and alanine aminotransferase (ALT) in the peripheral blood of the patients before and 24 weeks after treatment were detected. Liver stiffness was measured before and after treatment with Fibroscan liver fibrosis noninvasive detector. Results After DC-CIK combined with IFN- γ treatment, the level of HBV-DNA in peripheral blood of patients with chronic viral hepatitis type B was significantly decreased (7.04±1.02 vs. 5.62±1.99, P=0.001), and the response rate of virology was 56.7%. After DC-CIK combined with IFN-γ treatment, the liver hardness decreased significantly (9.65±3.75 vs. 6.63±2.48, P=0.000). Conclusions DC-CIK combined with IFN-γ can inhibit hepatitis B virus replication and inhibit liver fibrosis in patients with chronic viral hepatitis type B. Key words: Chronic viral hepatitis type B; Dendritic cell; Cytokine-induced killer cells; Interferon-γ; Liver fibrosis

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