Efficacy of Dapagliflozin & Metformin Vs Sitagliptin & Metformin in New patients with Type 2 Diabetic in HMC Hospital Peshawar

Abstract

Background: Efficacy of Dapagliflozin in combination with Metformin versus Sitagliptin in type 2 diabetic patients in hayat abad medical complex hospital Peshawar to check the efficacy of these anti Diabetic drug on patients and check the results of these two double combination drug using long tram and short tram treatment check effectiveness, safety side effects.
 Purpose: Randomized Measured study in Department of diabetes and Endocrinology HMC Hospital, Peshawar after the hospital ethical committee approval for one year i.e. 12-11-2017 to 12-12-2018 check the efficy of dapagliflozin in combination with metformin versus sitagliptin local setting.
 Methodology: three hundred subjects were selected via Hospital and opd, Patients were randomly divided into two groups. In Group-A, patients were given 100mg q.d sitagliptin plus 850 mg metformin twice a day. In Group-B, patients were given 10mg qd dapagliflozin plus 850mg metformin twice a day. Patients were followed up in OPD for 7/24 weeks. After 7/24 weeks, blood sample was obtained for assessment of HbA1c. Reports were measured and if HbA1c is < 6.0 then efficacy achieved. All this information was recorded on Performa.
 Results: the efficacy dapagliflozin and metformin versus sitagliptin and metformin in type 2 diabetes mellitus patients shows that 105(35.5% in Group A and 81(25.5%) in Group-B had efficacy and p value was 0.10.
 Conclusion: the study showed that Role of Efficacy of Metformin and Dapagliflozin is not significantly different when compared with Metformin and Sitagliptin in Diabetes Mellitus Type 2 patients.