Abstract
ABSTRACTBackground: Diversion colitis is still very common in our country, since the stoma creation is a common practice especially in situations of trauma. needing treatment for this condition. Aim: To evaluate the therapeutic effect of rectal infusion of Curcuma longa (turmeric) in the excluded intestinal segment of rats. Method: Eighteen Wistar rats were used and submitted to colostomy: control group (n=8) under rectal saline infusion and group CL, receiving intra-rectal infusion of Curcuma longa extract (n=10). After 21 days of treatment they were submitted to euthanasia; the intestinal segment excluded from intestinal transit was resected and sent to histopathological evaluation, classifying the degree of inflammation and of vascular congestion. Results: The average of inflammation was 2.7 in the control group vs. 2.6 in the CL group (p=0.3125), while the mean vascular congestion was 2.3 and 2.1, respectively, in the control and CL groups (p=0.1642). Conclusion: Intra-rectal infusion of Curcuma longa extract was not able to minimize the inflammatory process or vascular congestion in the diversion colitis of rats subjected to colostomy.
Highlights
Is still common to perform intestinal stomas around the world, especially in emergency procedures such as trauma, intestinal obstructions, perforations and inflammatory bowel diseases
The animals were assigned into two groups: 1) control group, n=8, subjected to infusion of saline solution for 21 days; 2) Curcuma longa group, n=10, subjected to colostomy and, after seven days, to the infusion of Curcuma longa enemas for 21 days
In relation to the degree of vascular congestion there was no difference between the groups, since in the control group thee observed mean was 2.3, while in the Curcuma longa group it was 2.1 (p=0.1642, Table 2)
Summary
Is still common to perform intestinal stomas around the world, especially in emergency procedures such as trauma, intestinal obstructions, perforations and inflammatory bowel diseases. These diversions are mainly made on a temporary basis; may become definitive because of the clinical conditions of the patients. The Hartmann’s procedure, when the sigmoid is externalized and the rectum excluded from the intestinal transit, corresponds to half of the intestinal transit deviations, making this type of stoma the one with the greatest number of complications, especially in the long term. In cases where the deviation remains for more than six months, the number of complications increases, among them, diversion colitis[11,13]. Diversion colitis can cause rectal pain in addition to mucopurulent secretion, ABCD Arq Bras Cir Dig 2019;32(3):e1456
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Arquivos brasileiros de cirurgia digestiva : ABCD = Brazilian archives of digestive surgery
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
