Efficacy of CT guided radioactive 125I seed implantation in the treatment of lung cancer

Abstract

Objective To investigate the feasibility,efficacy and complications of CT guided radioactive 125I seed implantation in the treatment of lung cancer.Methods According to the different treatment methods,65 patients with lung cancer were divided into two groups,37 cases in the implantation alone group received CT guided 125I seeds interstitial implantation,the other 28 cases in the combination treatment group received interstitial 125I seeds implantation combined with chemotherapy.All the patients were examined by posologic validation,and were followed up termly.Results The total effictive rate of 65 patients was 80.0％,1-year survival rate was 90.8％.The effictive rates of implantation alone group and combination treatment group were 67.6％ and 96.4％ respectively.There was a significant difference between the two groups (x2=8.298,P＜0.01).Before treatment,all the patients' mean diameter of the tumor was 5.48 cm; while it was 3.77 cm after treatment (t=7.764,P＜0.01).Complications included pneumothorax (36 cases),bloody sputum (7 cases),fever (4 cases) which improved after treatment in 65 patients,but without radiation pneumonia.Conclusion 125I seed implantation is a highly effective treatment without severe complications in the treatment of lung cancer. Key words: Lung neoplasms; Iodine radioisotopes; Brachytherapy; Tomography, X-ray computed