Abstract
We provide here an updated analysis on efficacy of COVID-19 vaccine booster doses in older people (i.e., aged ≥ 80years) based on ongoing Italian nationwide COVID-19 vaccination campaign. Data were obtained from the COVID-19 national integrated surveillance program, made available and regularly updated by the Italian National Institute of Health. Compared to those who completed the COVID-19 vaccination cycle for ≥ 5months (n = 2,385,897), those receiving booster doses (n = 1,549,747) had 75% lower risk of SARS-CoV-2 infection, 82-83% lower risk of COVID-19 hospitalization and ICU admission, and 81% lower risk of death. Administration of COVID-19 vaccine boosters generated also greater protection (between 63 and 87% higher) against all these same endpoints compared to early completing (i.e., < 5months; n = 335,458) a primary COVID-19 vaccination cycle. The administration of COVID-19 vaccine booster doses is advisable for reducing the risk of morbidity and mortality in older people.
Highlights
It is virtually undeniable that the ongoing coronavirus disease 2019 (COVID-19) pandemic is one of the most dramatic events that has challenged humanity since the former Spanish flu pandemic outbreak, in 1918–1919 [1]
This official bulletin includes complete nationwide epidemiologic information concerning the cumulative burden of COVID-19 cases, hospitalizations, intensive care unit (ICU) admissions and deaths, together with data on advancement of the nationwide COVID-19 vaccination campaign, which started on December 27, 2020
The administration of COVID-19 vaccine boosters generated greater protection against all these same endpoints compared to people who early completed (i.e., < 5 months) a primary COVID-19 vaccination cycle
Summary
It is virtually undeniable that the ongoing coronavirus disease 2019 (COVID-19) pandemic is one of the most dramatic events that has challenged humanity since the former Spanish flu pandemic outbreak, in 1918–1919 [1]. One of the most important aspects of this infectious respiratory disease, sustained by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is that older, fragile and comorbid people represent the most vulnerable part of the. The clinical evidence accumulated so far would suggest that older people should be especially protected from SARS-CoV-2 infection. Physical measures such as wearing face mask, social distancing, hand hygiene and so forth are only partially effective for preventing viral. This article is aimed at providing an analysis on efficacy of COVID-19 vaccine booster doses in older people based on data retrieved from the ongoing nationwide Italian COVID-19 vaccination campaign
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