Abstract

Acute liver failure (ALF) is a critical illness with high mortality. Plasma diafiltration (PDF) is a blood purification therapy in which simple plasma exchange is performed using a selective membrane plasma separator while the dialysate flows outside the hollow fibers. While several studies demonstrated that PDF therapy is a useful blood purification therapy for patients with ALF, PDF therapy is often difficult to employ in ALF patients complicated with multiple organ failure, especially in those with unstable hemodynamics. Furthermore, it is likely to re-occur immediately after PDF therapy. We developed continuous PDF (CPDF) as a new concept in PDF therapy, and assessed its efficacy and safety in ALF patients compared with conventional plasma exchange (PE) plus continuous hemodiafiltration (CHDF) therapy in this study.

Highlights

  • We aimed to audit the prescribing practice on a busy 14-bedd general ICU, and develop standardised practices and tools to improve safety

  • Pediatric pharmacists have been an integral part of the PICU rounds since 2002, their role has evolved over the course of years

  • From 1 January 2003 through 31 December 2012 pharmacists made 24,207 clinical interventions in the PICU and 19,252 of those interventions resulted in changes in medication therapy or therapy monitoring

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Summary

Introduction

We aimed to audit the prescribing practice on a busy 14-bedd general ICU, and develop standardised practices and tools to improve safety. The objective of our study was to implement a Post Arrest Consult Team (PACT) and improve the quality of care for admitted OHCA patients This retrospective audit evaluated adult patients who suffered in-hospital cardiac arrest (IHCA) against the recent National Confidential Enquiry into Patient Outcome and Death (NCEPOD) report [1]. It looked at the recognition of the acutely unwell, the interventions made, the decisions taken from admission through to the post-arrest period and the outcomes following cardiopulmonary resuscitation (CPR). Methods We conducted a chart review of all patients admitted to the Department of Critical Care (DCC) at our hospital following cardiac arrest over 2 years in 2010 to 2012 (Group 1). Methods A retrospective review was conducted looking at SICU patients managed with a normothermia protocol, with particular

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