Abstract
Purpose To investigate the efficacy of XingZhi-YiNao (XZYN) granules and hyperbaric oxygenation (HBO) for cognition and motor dysfunction in patients with delayed encephalopathy after acute carbon monoxide poisoning (DEACMP). Methods Eighty-nine patients with DEACMP were randomly divided into control group (n = 19), HBO group (n = 32), and XZYN group (n = 38). All patients received conventional treatment. HBO group received HBO therapy once daily. XZYN group received extra XZYN granules plus HBO treatment. The related indexes including activity of daily living (ADL) scale, Montreal cognitive assessment (MoCA) scale, and mini mental state examination (MMSE) scale were measured. Cerebral white matter injury, age related white matter changes (ARWMC) scale, and the amplitude and latency of P300 were assessed. Results Compared with control group, the neurological function scores of ADL, MoCA, and MMSE in HBO and XZYN groups were significantly improved, the impairment degree of brain white matter and cognition function were obviously alleviated, the latencies of P300 were significantly shortened, and the amplitudes of P300 were evidently increased (P < 0.05). Treatment efficacy of XZYN group was superior to that of HBO group (P < 0.05). Conclusion Combined XZYN granules and HBO can significantly improve cognition and motor functions in patients with DEACMP.
Highlights
Nowadays, carbon monoxide (CO) poisoning is the most common health problem for people in many countries [1]
Based on the statistical results, we found that there was no significant difference in activity of daily living (ADL), Montreal cognitive assessment (MoCA), and mini mental state examination (MMSE) scores among three groups prior to treatment (P > 0.05)
The scores of ADL, MoCA, and MMSE in both hyperbaric oxygen (HBO) group and XZYN group were significantly higher than those in control group after treatment (P < 0.05). Compared with those in HBO group, the scores of ADL, MoCA, and MMSE in XZYN group were apparently elevated at the same time point (Table 3, P < 0.05)
Summary
Carbon monoxide (CO) poisoning is the most common health problem for people in many countries [1]. In terms of the medicine application, more and more studies have paid attention to corticosteroids [7], Evidence-Based Complementary and Alternative Medicine antioxidants, and free radical scavengers [8, 9] Other drugs, such as brain-protective agents, traditional Chinese medicine (TCM), and natural animal and plant extracts [10,11,12], have been applied to clinical practice. These drugs can not fundamentally prevent or inhibit the occurrence and development of either acute brain damage or DEACMP due to the lack of evidence-based medicine. TCM may play a role in repairing the structure and function of damaged nerve cells, improving the neurological function in patients with severe acute CO poisoning and DEACMP
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