Abstract
Antioxidant therapy is a potentially promising approach to improve clinical outcomes for couples undergoing assisted reproduction techniques long-term. The review aims to (a) collate evidence for the effectiveness of combined oral antioxidant supplementation, including a head-to-head comparison in the treatment of male subfertility, and (b) investigate whether other intervention features, including duration, specific combinations, or dosage affect clinical outcomes in this population. Randomized controlled trials (RCTs) that examined the effectiveness of combined antioxidants on male subfertility, electronic databases including PubMed, Embase, CINAHL, PSYCHINFO, and Cochrane Central Register of Controlled Trials (CENTRAL) were searched. We also searched for unpublished data and references of identified articles. Two reviewers screened eligible studies according to pre-defined criteria and relevant data extracted. The Jadad scale assessed the quality of studies. The study used RevMan version 5.4.1 Meta-analysis software to analyze the effect of combination antioxidants for each outcome measure. Metadata was presented as relative risks for dichotomous outcomes and as standardized mean differences (or mean differences) for continuous outcomes. The systematic review and meta-analysis aimed to report available evidence of whether combination antioxidant is effective and safe in sub-fertile men undergoing assisted reproductive techniques. Also, this review highlighted whether any specific oral antioxidant combinations, dosage, or duration of therapy have a major influence on the clinical outcomes.
Highlights
IntroductionThe systematic review and meta-analysis aimed to report available evidence of whether combination antioxidant is effective and safe in sub-fertile men undergoing assisted reproductive techniques
Inclusion criteria In our search, accepted studies were to include the following characteristics: (a) antioxidant therapy analysed for patients after oral antioxidant; (b) Comparison of treatment of male subfertility c) available full text; d) parameters, and live birth rate; e) We included the most currently published articles only if studies show identical experiments; we included the individual study if different indicators were used
The evidence as discovered was low quality regarding the studies indicating that antioxidant supplementation in subfertile males will facilitate sperm quality and produce more live birth rates for couples visiting fertility clinics
Summary
The systematic review and meta-analysis aimed to report available evidence of whether combination antioxidant is effective and safe in sub-fertile men undergoing assisted reproductive techniques. Male subfertility is described as the inability morphology and/or motility in a minimum of one to achieve clinical pregnancy with frequent sample of two sperm analyses, gathered within a 1 and unprotected sexual intercourse after a year [1]. Meta-regression assessment of the infertile male [8] This test does analyses comprising over 184 studies concerning not certainly equate to reproductive outcomes and semen quality in recent times disclosed shocking data cannot distinguish infertile from fertile males
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