Abstract
Objectives: Orofacial pain can be caused by xerostomia, dental procedures, infections, and functional disorders in various areas, and it can greatly deteriorate patients’ quality of life. Thus, the present study aimed to investigate the efficacy of natural products in minimizing the side effects of synthetic drugs. Methods: In an experimental model of 4-DAMP-induced xerostomia, formalin was injected to induce inflammatory pain in the orofacial region, and the effects of oral administration of curcumin and cinnamon on pain behavioral response were observed. Results: In the experimental group with xerostomia, the pain response was prominent, which was suppressed in a concentration-dependent manner upon curcumin and cinnamon administration. Conclusions: Curcumin and cinnamon may be useful natural products for relieving the inflammatory orofacial pain caused by xerostomia.
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